JOHN R. TOBIN JR., M.D.
Of the relatively uncommon symptom complexes which comprise the adrenogenital syndrome, female pseudohermaphrodism is the most frequently encountered. An almost uniform abnormality of sex differentiation characterizes female pseudohermaphrodism and suggests that the excessive production of androgen by hyperplastic adrenals begins in the third to fifth month of embryonic development.1, a At birth these infants have ovaries, their müllerian duct system has undergone normal female development to form fallopian tubes, uterus and vagina, and the wolffian ducts have disappeared; but the genital duct continues to open into the urethra, forming a persistent urogenital sinus as in the male. After birth, rapid
TOBIN JR. CONGENITAL HYPERPLASIA OF THE ADRENALS IN THE FEMALE (FEMALE PSEUDOHERMAPHRODISM): THE REPORT OF A CASE TREATED WITH CORTISONE AND ESTROGEN1. Ann Intern Med. ;40:797–803. doi: 10.7326/0003-4819-40-4-797
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Published: Ann Intern Med. 1954;40(4):797-803.
Adrenal Disorders, Endocrine and Metabolism.
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