THEODORE S. EVANS, M.D., F.A.C.P.; CHARLES A. DOAN, M.D., F.A.C.P.
An increasing number of patients with known chronic constitutional disease are being recognized in whom, during a period of satisfactory therapeutic control, either basic qualitative cellular alterations occur, or complicating secondary cytopenic episodes16 develop, which are more immediately incapacitating and life-threatening than the primary dyscrasia itself. Under these circumstances, it is essential to reëvaluate promptly the fundamental underlying pathologic-physiology. It has been found to be most important to differentiate monocytopenia and pancytopenia particularly carefully, as due either to central bone marrow invasion or damage, or to some peripheral mechanism—with special reference to one of the so-called secondary hypersplenic or dysplenic
EVANS TS, DOAN CA. GIANT FOLLICLE HYPERPLASIA: A STUDY OF ITS INCIDENCE, HISTOPATHOLOGIC VARIABILITY, AND THE FREQUENCY OF SARCOMA AND SECONDARY HYPERSPLENIC COMPLICATIONS1. Ann Intern Med. ;40:851–880. doi: 10.7326/0003-4819-40-5-851
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Published: Ann Intern Med. 1954;40(5):851-880.
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