DONALD R. KORST
The purpose of this paper is to report a severe reaction to para-aminosalicylic acid (PAS) and to present a brief review of the literature concerning PAS reactions. Since the introduction of PAS as an antituberculous agent in 1946 by Lehman, based on the work of Bernheim, there has been a worldwide use of the drug in the treatment of tuberculosis. The efficacy of PAS was confirmed by Sievers and Youmans and in 1949 Block et al. suggested that PAS in combination with streptomycin would aid in preventing development of drug resistance. Since then PAS has become accepted as a part
KORST DR. SEVERE REACTIONS TO PARA-AMINOSALICYLIC ACID: A CASE REPORT AND BRIEF REVIEW OF LITERATURE1. Ann Intern Med. 1954;40:1011–1016. doi: 10.7326/0003-4819-40-5-1011
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Published: Ann Intern Med. 1954;40(5):1011-1016.
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