THOMAS C. HALL, M.D.; VINCENT DI RAIMONDO, M.D.
Since concentrated human serum albumin has become available, it has been used extensively as ideal for parenteral protein replacement, and as a plasma volume expander.1 It is estimated2 that to date, 2,300,000 units of 25 gm. each have been prepared in the United States according to the method of Cohn and his associates.3 Although "anaphylactoid,"4 pyrogenic and hemodynamic5 reactions have been noted to follow intravenous injections of human serum albumin, none due to natural or acquired sensitivity has been reported. Hence the development of sensitivity after repeated administration of albumin, with the appearance of precipitins in the serum of a
HALL TC, DI RAIMONDO V. ACQUIRED SENSITIVITY TO HUMAN ALBUMIN FOLLOWING ALBUMIN TREATMENT OF IDIOPATHIC HYPOPROTEINEMIA1. Ann Intern Med. ;40:1017–1023. doi: 10.7326/0003-4819-40-5-1017
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Published: Ann Intern Med. 1954;40(5):1017-1023.
Hematology/Oncology, Hospital Medicine.
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