CHARLES WILLIAM SMITH, M.D., F.A.C.P.; KENNETH E. QUICKEL, M.D., F.A.C.P.; ARTHUR E. BROWN, M.D.; CHESTER G. THOMAS, M.D.
Most clinicians1, 2, 3 who first investigated cation exchange resins to control edema tempered their enthusiasm for this therapy with precautions. Although they found that such resins removed sodium and thereby effectively reduced extracellular fluids, they recommended that patients taking them be followed with many chemical tests. Their precautionary recommendation appeared necessary because of the effect of the resins on electrolyte balance.
The following complications1, 4, 5, 6, 7, 8, 9 have been noted in the literature. Acidosis, a not infrequent disturbance, was noted early in the use of resin therapy. These early resins exchanged hydrogen ions for the positive
SMITH CW, QUICKEL KE, BROWN AE, THOMAS CG. HOW SAFE IS CATION EXCHANGE RESIN THERAPY WHEN USED IN PRIVATE PRACTICE? A CLINICAL STUDY AND PARALLEL LABORATORY STUDY1. Ann Intern Med. ;40:1169–1176. doi: 10.7326/0003-4819-40-6-1169
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Published: Ann Intern Med. 1954;40(6):1169-1176.
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