ERNEST JAWETZ, M.D., Ph.D.; VIRGINIA COLEMAN, B.A.; JANET B. GUNNISON, M.A.
The polymyxins are a group of stable basic polypeptides isolated from Bacillus polymyxa.1 Depending upon their amino acid composition, they have been designated by letters A, B, C, D and E. Polymyxins A and D possess significant nephrotoxic action and are no longer employed in therapy. Polymyxins B and E produce annoying, though harmless, neurotoxic side effects but are not significantly nephrotoxic if administered intramuscularly in doses not exceeding 2.5 mg./kg./day to persons with good renal function.2, 3 These drugs are rapidly bactericidal for gram-negative organisms and have been particularly useful in the management of infections due to Pseudomonas aeruginosa.3,
JAWETZ E, COLEMAN V, GUNNISON JB. THE PARTICIPATION OF POLYMYXIN B IN COMBINED ANTIBIOTIC ACTION1. Ann Intern Med. 1954;41:79–88. doi: 10.7326/0003-4819-41-1-79
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Published: Ann Intern Med. 1954;41(1):79-88.
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