KERMIT E. OSSERMAN, M.D., F.A.C.P.; LAWRENCE I. KAPLAN, M.D.
In 1935 neostigmine1 was introduced as an agent for the treatment of myasthenia gravis. It is still the drug of choice but, because of the frequency of dosage and the development of refractoriness in some patients, there has been a concentrated search for another, more nearly ideal therapeutic agent.
In recent years potent anticholinesterase (antiChE) drugs, the alkyl phosphates, were introduced for the treatment of myasthenia gravis. These include di-isopropyl fluorophosphate (DFP),2 tetraethylpyrophosphate (TEPP),3 and hexaethyltetraphosphate (HETP).4 DFP was found to be a very effective antiChE agent, but toxic and not effective therapeutically. HETP and TEPP were found to be
OSSERMAN KE, KAPLAN LI. STUDIES IN MYASTHENIA GRAVIS: PRESENT STATUS OF THERAPY WITH OCTAMETHYL PYROPHOSPHORAMIDE (OMPA)1. Ann Intern Med. ;41:108–111. doi: 10.7326/0003-4819-41-1-108
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Published: Ann Intern Med. 1954;41(1):108-111.
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