JOHN B. VANDER, M.D.
The extremely variable clinical manifestations of infectious mononucleosis may best be understood from studies1 of the histologic features of the disease. These have shown widespread cellular infiltrations involving almost every organ in the body. While the lymph nodes and spleen usually are involved, pathologic changes are also common in the liver, kidney, heart, testis, central nervous system and lung. These changes are described as multiple localized infiltrations of mononuclear cells and small lymphocytes which may compress or replace normal parenchyma. The clinical pattern accordingly will vary with the organs affected, and the great diversity of symptoms is explained by the
VANDER JB. PLEURAL EFFUSION IN INFECTIOUS MONONUCLEOSIS1. Ann Intern Med. 1954;41:146–151. doi: 10.7326/0003-4819-41-1-146
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Published: Ann Intern Med. 1954;41(1):146-151.
Infectious Disease, Pulmonary/Critical Care.
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