ALTON M. PAULL, M.D.; ARTHUR M. PHILLIPS, M.D.
It is now believed that the diverse manifestations of reticuloendotheliosis are merely different phases of one disease.1, 2, 3, 4 The clinical picture produced depends on the rapidity of the pathologic process and the locations involved by the lesions. The more rapidly progressive and disseminated form described chiefly in infants and young children is characterized by generalized adenopathy, often hepatosplenomegaly, fever, purpura, anemia, cachexia and a fatal outcome.5 Although rare, similar cases have been described in adults.6, 7 The more chronic form of the disease usually evidences itself as either xanthoma disseminata of the skin, eosinophilic granuloma of bone, the
PAULL AM, PHILLIPS AM. SYSTEMIC RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE) IN THE ADULT MALE1. Ann Intern Med. 1954;41:363–371. doi: 10.7326/0003-4819-41-2-363
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Published: Ann Intern Med. 1954;41(2):363-371.
Interstitial Lung Disease, Pulmonary/Critical Care.
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