ANANDA S. PRASAD, M.D.; DONALD W. KOZA, M.D.
Agammaglobulinemia is a syndrome first described by Bruton in 1952,1 and later elaborated upon further by Bruton and Janeway2 in the same year. This syndrome is featured by (a) a history of recurrent bacterial infections, (b) absence of acquired antibodies, (c) lack of isohemagglutins, (d) extremely low to absent gamma globulin, although total serum proteins are within normal range, (e) failure of long-term antibiotic therapy to furnish protection, and (f) response to protective injections of gamma globulin.
This 30 year old white female was admitted to Ancker Hospital on November 21, 1953, with a diagnosis of meningitis.
PRASAD AS, KOZA DW. AGAMMAGLOBULINEMIA(AGAMMAGLOBULINEMIA*). Ann Intern Med. 1954;41:629–639. doi: 10.7326/0003-4819-41-3-629
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Published: Ann Intern Med. 1954;41(3):629-639.
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