W. RAAB, M.D., F.A.C.P.
Three cardinal features of cardiac pathology—myocardial hypertrophy, myocardial structural degeneration and myocardial functional weakness—are by tradition ascribed to primarily mechanical factors, namely, increased hemodynamic resistance or decreased coronary blood flow or both. The inadequacy of such oversimplification is becoming increasingly obvious in the light of our growing comprehension of underlying myocardial metabolic anomalies, especially those induced or enhanced by the action of neurohormones (adreno-sympathogenic catecholamines) and hormones (adrenal mineralo-corticoids and thyroid hormone).
1. The phenomenon of cardiac hypertrophy depends to a much lesser extent on the mechanical "burden" of increased peripheral resistance than is generally believed. This is exemplified by
RAAB W. HORMONAL FACTORS IN HEART DISEASE: THEIR ROLE IN MYOCARDIAL HYPERTROPHY, HYPOXIA AND ELECTROLYTE IMBALANCE1. Ann Intern Med. 1954;41:757–763. doi: 10.7326/0003-4819-41-4-757
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Published: Ann Intern Med. 1954;41(4):757-763.
Cardiology, Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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