GORDON C. MEACHAM, M.D.; AUSTIN S. WEISBERGER, M.D.
The diagnosis of leukemia by clinical and laboratory studies is usually not difficult. Occasionally, however, the initial manifestations of the leukemic process may be atypical and precede the onset of clinically recognizable leukemia by several years. The abnormal hematologic findings are not specific and consist of various combinations of anemia, leukopenia, neutropenia and thrombocytopenia, with a hyperactive marrow. The spleen is usually not palpable or only slightly enlarged. Initially these cases often resemble the syndrome usually designated as "primary" splenic panhematopenia.1, 2 The following report deals with 10 patients manifesting the above findings who were studied during the past five
MEACHAM GC, WEISBERGER AS. EARLY ATYPICAL MANIFESTATIONS OF LEUKEMIA1. Ann Intern Med. ;41:780–797. doi: 10.7326/0003-4819-41-4-780
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Published: Ann Intern Med. 1954;41(4):780-797.
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