WILLIAM H. WAUGH, M.D.
The antipyretic and hypothermic effects of corticotropin and cortisone are well documented. Kass and Finland1 showed that the febrile response to injections of typhoid bacilli and influenza virus could be lessened by corticotropin. Douglas and Paton2 demonstrated that corticotropin reduced the temperature both in normal animals and in experimental pyrexia. Therapeutically, adrenocortical hormones have been used to alleviate the pyrexia and toxemia of pneumonia,3 typhoid fever,4, 5 Rocky Mountain spotted fever6 and generalized peritonitis.7
Ingraham, Matson and McLaurin8 suggested that corticotropin and cortisone might help prevent the hyperthermia of hypothalamic damage which sometimes results from surgery for craniopharyngiomas. They observed
WAUGH WH. CORTISONE AND THE TREATMENT OF HEAT STROKE1. Ann Intern Med. ;41:841–843. doi: 10.7326/0003-4819-41-4-841
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Published: Ann Intern Med. 1954;41(4):841-843.
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