BENNETT LEVINE, M.D.; DAVID V. ROSENBERG, M.D.
Since the introduction of thiouracil for the treatment of hyperthyroidism there has been a constant search for more potent and less toxic antithyroid drugs. None of these drugs, however, is free from a variety of undesirable toxic side effects. At the present time propylthiouracil and Tapazole (1-methyl-2-mercaptoimidazole) are the drugs most frequently employed because of their proved efficacy and the relatively low incidence of toxic side reactions. Toxic reactions of all types with propylthiouracil have occurred in 1.6 to 3.2 per cent of cases.1-4 Severe leukopenia and agranulocytosis have occurred in 0.5 to 1.0 per cent of patients,2-9 and several
LEVINE B, ROSENBERG DV. APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLE1. Ann Intern Med. 1954;41:844–848. doi: 10.7326/0003-4819-41-4-844
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Published: Ann Intern Med. 1954;41(4):844-848.
Endocrine and Metabolism, Hematology/Oncology, Red Cell Disorders, Thyroid Disorders.
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