MILTON S. SACKS, M.D.
In 1923 Taliaferro and Huck1 proposed the theory that sickle cell disease, first described by Herrick2 in 1910, was due to the inheritance of an abnormal gene which behaved as a Mendelian dominant characteristic. Clinical variation in severity, characterized as sicklemia (sickle cell trait) and sickle cell anemia respectively, was believed due to a difference in penetrance or expression of the abnormal gene. In vitro demonstration of sickling by exposure of erythrocytes to reduced oxygen tension, does not permit differentiation of the two clinical states. In 1940 Sherman3 noted that a considerably greater reduction in oxygen tension was required to
MILTON S. SACKS. HEREDITARY HEMOGLOBINOPATHIES. Ann Intern Med. 1954;41:849–854. doi: 10.7326/0003-4819-41-4-849
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Published: Ann Intern Med. 1954;41(4):849-854.
Hematology/Oncology, Red Cell Disorders.
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