ALFRED M. WEDD, M.D., F.A.C.P.; STEPHEN M. TENNEY, M.D.
The production of delirium cordis by coronary artery ligation or electrical stimulation of the ventricle was known long before Vulpian1 by faradization converted the normal systole of either auricle or ventricle into the tremulous movement which he called fibrillation. In 1887 MacWilliam2 demonstrated that this phenomenon was entirely muscular and that "heightened irritability" and delayed conduction were essential to its production. Through the years there have been many theories for the genesis of cardiac arrhythmias, two of which continue to receive attention, namely, reëntry of impulses and ectopic pacemakers. Mines3 showed that what he called a circulating excitation, already known
WEDD AM, TENNEY SM. FACTORS CONCERNED IN THE GENESIS OF CARDIAC ARRHYTHMIAS1. Ann Intern Med. ;41:935–941. doi: 10.7326/0003-4819-41-5-935
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Published: Ann Intern Med. 1954;41(5):935-941.
Cardiology, Rhythm Disorders and Devices.
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