JEROME RADDING, M.D.; MARSHALL J. FIESE, M.D.
In 1907 Whipple1 reported a previously undescribed disease which occurred in a 36 year old physician and was manifested by vague abdominal distress, progressive weight loss, diarrhea, arthralgia and generalized pigmentation. Stool examination showed a great increase in neutral fat and fatty acids. The patient died following an exploratory laparotomy, and microscopic examination revealed an accumulation of mononuclear foam cells in the lamina propria of the small intestine and in the enlarged mesenteric lymph nodes. Whipple named the disease intestinal lipodystrophy, and felt that it was due to some disorder of fat metabolism.
Since Whipple's description of this disease 52
RADDING J, FIESE MJ. WHIPPLE'S DISEASE (INTESTINAL LIPODYSTROPHY): REVIEW OF THE LITERATURE AND REPORT OF A CASE SUCCESSFULLY TREATED WITH ADRENOCORTICOTROPIN (ACTH) AND CORTISONE1. Ann Intern Med. 1954;41:1066–1075. doi: 10.7326/0003-4819-41-5-1066
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Published: Ann Intern Med. 1954;41(5):1066-1075.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Infectious Disease.
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