HUGH P. SMITH, M.D., F.A.C.P.; HUGH P. SMITH JR., M.D.
Ochronosis is a rare but fascinating metabolic disorder which is sometimes startling for its discoloration of the cartilages, sclerae and other areas. In most well studied cases it seems to be secondary to alkaptonuria, which is usually congenital in origin, and ordinarily seems to be a Mendelian recessive trait, although in some families it has been transmitted as a dominant characteristic.1, 2 In addition, there have been cases reported secondary to prolonged exposure to carbolic acid,3 particularly when it was used as a continuous moist dressing for a chronic cutaneous ulcer. Since this custom has practically disappeared, nearly all cases
SMITH HP, SMITH HP. OCHRONOSIS: REPORT OF TWO CASES1. Ann Intern Med. ;42:171–178. doi: 10.7326/0003-4819-42-1-171
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Published: Ann Intern Med. 1955;42(1):171-178.
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