EDWARD KESSLER, M.D.
Hypercalcemia associated with renal insufficiency has been reported in vitamin D intoxication,1, 2 hyperparathyroidism,3 acute osteoporosis,4 sarcoidosis,3, 5, 6 carcinomatosis with bone involvement3, 7 and multiple myeloma.3, 8 In 1949 the details of a new syndrome occurring in patients with symptoms of peptic ulcer ingesting large amounts of milk and absorbable alkali, and characterized by hypercalcemia (without hypercalciuria or hypophosphatemia), calcinosis and renal insufficiency, were described by Burnett, Commons, Albright and Howard.9 Additional reports have appeared subsequently in the literature.10-13, 27-30
At a single hospital within a one-year period, out of a total of 291 patients with peptic ulcer, three
EDWARD KESSLER. HYPERCALCEMIA AND RENAL INSUFFICIENCY SECONDARY TO EXCESSIVE MILK AND ALKALI INTAKE(HYPERCALCEMIA AND RENAL INSUFFICIENCY SECONDARY TO EXCESSIVE MILK AND ALKALI INTAKE*). Ann Intern Med. 1955;42:324–338. doi: 10.7326/0003-4819-42-2-324
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Published: Ann Intern Med. 1955;42(2):324-338.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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