FRANCIS J. CATANZARO; LORING BROCK; ROBERT CHAMOVITZ; WILLIAM D. PERRY; ALAN C. SIEGEL; CHANDLER A. STETSON; CHARLES H. RAMMELKAMP JR., M.D., F.A.C.P.; HAROLD B. HOUSER; BERTRAND L. STOLZER; LEWIS W. WANNAMAKER; EDWARD O. HAHN
Although penicillin, Chlortetracycline, Oxytetracycline and erythromycin have been shown to be effective in alleviating the symptoms of acute streptococcal disease, only penicillin and Chlortetracycline therapy have been shown to reduce the incidence of rheumatic fever following such infections.1-6 Since an important purpose of treatment is the prevention of complications, particularly rheumatic fever, it is necessary to evaluate the antirheumatic effect of each new drug employed in the therapy of streptococcal infections. In addition, the occurrence of reactions to the various drugs makes it essential that more than one form of therapy be available to the physician.
The present study is
CATANZARO FJ, BROCK L, CHAMOVITZ R, PERRY WD, SIEGEL AC, STETSON CA, et al. EFFECT OF OXYTETRACYCLINE THERAPY OF STREPTOCOCCAL SORE THROAT ON THE INCIDENCE OF ACUTE RHEUMATIC FEVER1. Ann Intern Med. ;42:345–357. doi: 10.7326/0003-4819-42-2-345
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Published: Ann Intern Med. 1955;42(2):345-357.
Infectious Disease, Streptococcal Infections.
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