ALLEN I. BORTZ, M.D.; FRANK H. BETHELL, M.D., F.A.C.P.
The complete syndrome of intestinal polyposis and melanin spots of the oral mucosa, lips and digits was first described by Jeghers1 in 1944. However, as early as 1896 Hutchinson2 reported unusual black pigmented spots on the face and oral mucosa of twins, and Weber3 in 1919 reported that one of these twins died of intussusception at the age of 20. Peutz4 in 1921 demonstrated a familial incidence of this syndrome by finding both pigmentation and intestinal polyposis affecting several members of the same family. He apparently did not believe that there was an important association between the two components of
BORTZ AI, BETHELL FH. PIGMENTED SPOTS OF THE ORAL MUCOSA, LIPS AND DIGITS ASSOCIATED WITH GASTROINTESTINAL POLYPOSIS1. Ann Intern Med. ;42:424–432. doi: 10.7326/0003-4819-42-2-424
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Published: Ann Intern Med. 1955;42(2):424-432.
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