BERNARD STRAUS, M.D., F.A.C.P.; JULIUS EISENBERG, M.D.; JOSEPH GENNIS, M.D., F.A.C.P.
It is widely recognized that one of the important side effects of the antihistamines as a class is their sedative action; it has also been considered the most characteristic.1 Controlled studies of their hypnotic (sleep-inducing) effect, however, are lacking. This side effect may be either desirable or objectionable, depending on the situation in which the drug is employed. It was obvious that such a side effect might be used to good advantage as a primary action, i.e., the use of antihistamines as hypnotics. This would seem to be of some value, since the toxicity of this class of compounds is
STRAUS B, EISENBERG J, GENNIS J. HYPNOTIC EFFECTS OF AN ANTIHISTAMINE—METHAPYRILENE HYDROCHLORIDE1. Ann Intern Med. ;42:574–582. doi: 10.7326/0003-4819-42-3-574
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Published: Ann Intern Med. 1955;42(3):574-582.
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