RAYMOND S. JACKSON, M.D.; CHAS. F. WILKINSON JR., M.D., F.A.C.P.; LAWRENCE MEYERS, M.D., F.A.C.P.; MICHAEL S. BRUNO, M.D.; MARTIN R. BENJAMIN, M.D.
The question of whether lipotropic agents might have an effect upon atherosclerosis has been the basis for a number of studies in animals and in man. Clinical investigations have followed along two general lines. Attempts at direct therapeutic evaluation have depended upon the administration of a test substance to patients who have recovered from a myocardial infarction, comparing their course with that of an untreated group of coronary survivors. Strict comparability of methods of managing the basic disease and all concomitant diseases in both the treated and control groups is a necessary part of such a clinical test.
JACKSON RS, WILKINSON CF, MEYERS L, BRUNO MS, BENJAMIN MR. AN EVALUATION OF THE EFFECT OF CHOLINE AND INOSITOL ON THE CLINICAL COURSE AND SERUM LIPIDS IN PATIENTS WITH ANGINA PECTORIS1. Ann Intern Med. ;42:583–594. doi: 10.7326/0003-4819-42-3-583
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Published: Ann Intern Med. 1955;42(3):583-594.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Dyslipidemia.
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