RUSSELL H. WILSON, M.D., Ph.D.; WAYNE HOSETH, M.D.; MARY E. DEMPSEY, M.S.
It is well established, experimentally, that acute hypoxia causes a significant elevation of the pulmonary arterial blood pressure. The magnitude of the rôle of chronic hypoxia in increasing the pulmonary vascular resistance leading to increased pressure in the lesser circulation has not been clearly defined. Efforts have been made to separate the effects of changes in the magnitude of cardiac output and pulmonary vascular resistance on the pulmonary arterial pressure, but the relationship of each phenomenon to acute and chronic pulmonary hypertension has not been clearly established.
Von Euler and Liljestrand1 found that in cats the pulmonary arterial pressure increased
WILSON RH, HOSETH W, DEMPSEY ME. THE EFFECTS OF BREATHING 99.6% OXYGEN ON PULMONARY VASCULAR RESISTANCE AND CARDIAC OUTPUT IN PATIENTS WITH PULMONARY EMPHYSEMA AND CHRONIC HYPOXIA1. Ann Intern Med. 1955;42:629–637. doi: 10.7326/0003-4819-42-3-629
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Published: Ann Intern Med. 1955;42(3):629-637.
Cardiac Diagnosis and Imaging, Cardiology, Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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