F. T. BILLINGS JR., M.D., F.A.C.P.; O. A. COUCH JR., M.D.
The cause of calcification of the pericardium in many instances is obscure. Agreement can be reached regarding etiology only in the statement that "calcification occurs as a secondary degenerative change complicating chronic inflammation of the pericardium."1 In the majority of cases, by the time bacteriologic and pathologic studies can be undertaken, evidence of specific infection or injury is not demonstrable. It is intriguing to note that whenever disease entities are implicated, authorities are dogmatic in their differences of opinion. For example, while Paul, Castleman and White2 in Boston found no evidence which would incriminate rheumatic fever, Smith and Willius3 in
BILLINGS FT, COUCH OA. PERICARDIAL CALCIFICATION AND HISTOPLASMIN SENSITIVITY1. Ann Intern Med. ;42:654–658. doi: 10.7326/0003-4819-42-3-654
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Published: Ann Intern Med. 1955;42(3):654-658.
Cardiology, Pericardial Disease.
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