ARTHUR A. COOPERBERG, M.D.; GREGORY M. A. NEIMAN, M.D.
Fibrinogenopenia in leukemia is a rare occurrence, according to the literature. Risak8 reported a marked fibrinogenopenia in three patients with acute myelogenous leukemia who died of severe bleeding. He assumed an impaired production of fibrinogen as the cause of the fibrinogenopenia, but tests for fibrinolysis were not carried out in these cases.
In the case reported below a reduction in plasma fibrinogen was discovered in the course of examination of the blood. Further studies revealed the presence of a fibrinolysin, which was believed to be the cause of the fibrinogenopenia. In recent years the appearance of a fibrinolysin and fibrinogenopenia
COOPERBERG AA, NEIMAN GMA. FIBRINOGENOPENIA AND FIBRINOLYSIS IN ACUTE MYELOGENOUS LEUKEMIA1. Ann Intern Med. ;42:706–711. doi: 10.7326/0003-4819-42-3-706
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Published: Ann Intern Med. 1955;42(3):706-711.
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