SAMUEL ALPERT, M.D.
Despite intensive investigative work, diabetes mellitus remains a disorder of unknown etiology whose clinical manifestations constitute a symptom complex composed of impaired glucose tolerance, neuropathy, nephropathy, retinopathy and accelerated atherosclerosis. The site of the anatomic defect remains obscure. There is no indication that the primary basic pathology is wholly confined to the pancreas, nor is there evidence that excessive carbohydrate consumption is in any way related to the development of the disorder. On the other hand, any primary affliction of the pancreas may give rise to carbohydrate disturbances indistinguishable from that seen in true diabetes mellitus by reason of diminished
ALPERT S. IMPAIRED GLUCOSE TOLERANCE, A CONSEQUENCE OF EXCESSIVE CARBOHYDRATE CONSUMPTION1. Ann Intern Med. ;42:927–931. doi: 10.7326/0003-4819-42-4-927
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Published: Ann Intern Med. 1955;42(4):927-931.
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