PAUL W. CLOUGH
Treatment of severe staphylococcal infections has always presented difficult problems which have by no means been eliminated by the advent of antibacterial drugs. The sulfonamides furnished relatively little help, although sulfathiazole for a time proved effective in many cases of staphylococcal infection of the urinary passages and occasionally in generalized infections.
The advent of penicillin, however, apparently opened up a new era when it was found that these organisms were almost uniformly sensitive to penicillin and that the drug was highly effective clinically. The immediate result, when adequate quantities of penicillin were available, was a marked reduction in mortality and
CLOUGH PW. RESISTANCE OF MICROCOCCI (STAPHYLOCOCCI) TO ANTIBIOTICS. Ann Intern Med. ;42:954–959. doi: 10.7326/0003-4819-42-4-954
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Published: Ann Intern Med. 1955;42(4):954-959.
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