NORMAN ENDE, M.D.; PHILIP PIZZOLATO, M.D.; JOSEPH ZISKIND, M.D., F.A.C.P.
Sickle cell anemia has long been known to produce severe clinical manifestations. Only recently, however, has it been accepted that the sickle cell trait per se, or sicklemia, is also capable of producing clinical symptoms and pathologic findings.1 Although prior to 1940 some cases of sicklemia had been reported2 which showed clinical findings with no anemia, it was not until that year that Bauer3 introduced the idea that the anemic picture was but one manifestation of sickle cell disease.
The most recent combined surveys show a 9.0% incidence of sickling4 in the Negro population of the United States. Despite these
ENDE N, PIZZOLATO P, ZISKIND J. SICKLEMIA12. Ann Intern Med. ;42:1065–1075. doi: 10.7326/0003-4819-42-5-1065
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Published: Ann Intern Med. 1955;42(5):1065-1075.
Hematology/Oncology, Red Cell Disorders.
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