MORTON SCHWARTZ, M.D.; RICHARD A. GILMAN, M.D.; JOHN S. ROBEY, M.D.; JANET SETTLE, M.D.; LELAND E. PADDOCK, M.D.
In the past the prognosis of tuberculomas of the central nervous system has been considered grave, primarily because of the usual progression to tuberculous meningitis, either spontaneously or as the aftermath of attempted surgical intervention. As recently as 1932 Cushing advocated decompression as the only surgical procedure for these lesions.1 Surgical results remained poor1, 2 until the introduction of the antituberculous chemotherapeutic agents, streptomycin and p-aminosalicylic acid (PAS) to combat and prevent the complicating meningitis. With the addition of isoniazid to the therapeutic armamentarium, another potent agent is now available. Because of these advances, the previous pessimistic attitude toward surgical
SCHWARTZ M, GILMAN RA, ROBEY JS, SETTLE J, PADDOCK LE. TUBERCULOMAS OF THE CENTRAL NERVOUS SYSTEM: REVIEW AND REPORT OF FOUR CASES SUCCESSFULLY MANAGED WITH SURGERY AND CHEMOTHERAPY1. Ann Intern Med. ;42:1076–1088. doi: 10.7326/0003-4819-42-5-1076
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Published: Ann Intern Med. 1955;42(5):1076-1088.
Infectious Disease, Mycobacterial Infections, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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