J. RICHARD JOHNSON; WINTHROP N. DAVEY, F.A.C.P.
Corticotropin (ACTH) and cortisone are regarded as contraindicated in the presence of tuberculosis because of their suppressive effect on inflammation, granulation tissue formation and fibroblastic repair.1-4 Enhancement of tuberculosis in experimental animals by these drugs has been reported in numerous studies5-10 but not in all.11-17 Likewise they have been reported to have caused progression or reactivation of pulmonary tuberculosis in the human,18-22 and their use has been accompanied by the appearance of pulmonary or disseminated tuberculosis in some individuals not previously known to have tuberculosis.23-32
It is not certain that the simultaneous use of antimicrobial drugs will prevent progression
JOHNSON JR, DAVEY WN. TREATMENT OF A PATIENT WITH LUPUS ERYTHEMATOSUS AND PULMONARY TUBERCULOSIS WITH ACTH, STREPTOMYCIN AND PARA-AMINOSALICYLIC ACID1. Ann Intern Med. ;42:1109–1118. doi: 10.7326/0003-4819-42-5-1109
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Published: Ann Intern Med. 1955;42(5):1109-1118.
Infectious Disease, Lupus Erythematosus, Mycobacterial Infections, Pulmonary Tuberculosis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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