MARSHALL J. FIESE, M.D.; STEPHEN CHEU, M.D.; ROYAL H. SORENSEN, B.S.
For half a century it has been known that Coccidioides immitis ordinarily exists in two distinct phases, the saprophytic and the parasitic, the former occurring in external nature and culture media, and the latter, in animal tissues. The biphasic life cycle of the fungus was first outlined by Ophüls,1 and was more extensively delineated by Baker, Mrak and Smith.2
The usual life cycles of the fungus are as follows:
Parasitic Cycle: The injected or inhaled arthrospore or chlamydospore becomes rounded and shows the doubly refractile walls of the spherule or sporangium. Its protoplasm divides by cleavage planes to form endospores,
FIESE MJ, CHEU S, SORENSEN RH. MYCELIAL FORMS OF COCCIDIOIDES IMMITIS IN SPUTUM AND TISSUES OF THE HUMAN HOST1. Ann Intern Med. ;43:255–270. doi: 10.7326/0003-4819-43-2-255
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Published: Ann Intern Med. 1955;43(2):255-270.
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