THOMAS H. BREM, M.D.; M. E. MORTON, M.D.
The anomaly called agammaglobulinemia has become a fairly well known clinical entity, although prior to Bruton's report1 in 1952 it had never been described. The subject of his study was an eight year old boy who for four years had had a continuous series of bacterial and viral infections. Electrophoretic studies of the serum proteins led to the surprising discovery of complete absence of the gamma fraction in an otherwise normal serum protein pattern. Immunologic studies disclosed the complete lack of antibodies, including isohemagglutinins, and repeated challenge with a number of antigens failed to evoke an antibody response.
BREM TH, MORTON ME. DEFECTIVE SERUM GAMMA GLOBULIN FORMATION(DEFECTIVE SERUM GAMMA GLOBULIN FORMATION*). Ann Intern Med. 1955;43:465–479. doi: 10.7326/0003-4819-43-3-465
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Published: Ann Intern Med. 1955;43(3):465-479.
Gastroenterology/Hepatology, Hematology/Oncology, Hospital Medicine, Leukemia/Lymphoma, Liver Disease.
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