DONALD R. NICHOLS, M.D.; WILLIAM J. MARTIN, M.D.
Cryptococcosis (torulosis) is an infection which occurs more frequently than is generally appreciated. Clinically the early diagnosis of this disease is difficult. However, if the possibility of cryptococcosis is considered in the differential diagnosis of any chronic infection or of any disease of obscure origin, the diagnosis might be made more frequently.
Cryptococcosis is caused by a yeastlike fungus, Cryptococcus neoformans (Torula histolytica). Infections caused by this organism usually terminate in fatal meningo-encephalitis. However, the fact that lesions elsewhere in the body often precede the lesions in the central nervous system is sometimes overlooked. Often signs and symptoms produced by
NICHOLS DR, MARTIN WJ. CRYPTOCOCCOSIS: CLINICAL FEATURES AND DIFFERENTIAL DIAGNOSIS(CRYPTOCOCCOSIS: CLINICAL FEATURES AND DIFFERENTIAL DIAGNOSIS*). Ann Intern Med. 1955;43:767–780. doi: 10.7326/0003-4819-43-4-767
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Published: Ann Intern Med. 1955;43(4):767-780.
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