MILTON J. STEINHARDT, M.D.; GEORGE S. FISHER, M.D., F.A.C.P.
During the past two decades numerous reports have appeared in the medical literature describing a serum protein which precipitates on exposure to cold.1, 2, 9, 14, 22, 23, 34, 35, 38, 42, 46 This protein has been called cryoglobulin, and occurs in association with or secondary to a variety of disease processes. It is our purpose to report an unusual case of cryoglobulinemia, under our observation for three years, in which no such underlying disease was found present (table 1).
A 45 year old white housewife was first seen in September, 1951, complaining of cold urticaria. Her symptoms
STEINHARDT MJ, FISHER GS. ESSENTIAL CRYOGLOBULINEMIA1. Ann Intern Med. ;43:848–858. doi: 10.7326/0003-4819-43-4-848
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Published: Ann Intern Med. 1955;43(4):848-858.
Coagulopathies, Hematology/Oncology, Nephrology.
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