WILLIAM N. CHAMBERS, M.D., F.A.C.P.; JOHN MILNE, M.D., F.A.C.P.
Myxedema is uncommon in young males and its occurrence in siblings is rare. It is a common but frequently unrecognized cause of organic psychosis.
Nearly half the patients cited by the Committee on Myxoedema1 had some form of mental disturbance. The psychotic manifestations of myxedema may exhibit themselves before the classic picture of the disease has developed and may be the first obvious evidence of altered thyroid function.2 The psychosis which is dependent on myxedema occurs in 15% of patients, usually when the myxedema is advanced.3 This psychosis does not represent any specific type, but there is common behavior
CHAMBERS WN, MILNE J. MYXEDEMA IN TWO BROTHERS, ONE WITH PSYCHOSIS12. Ann Intern Med. ;43:892–903. doi: 10.7326/0003-4819-43-4-892
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Published: Ann Intern Med. 1955;43(4):892-903.
Endocrine and Metabolism, Thyroid Disorders.
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