GEORGE W. THORN, M.D., F.A.C.P.; ALBERT E. RENOLD, M.D.; WILLIAM I. MORSE, M.D.; ALAN GOLDFIEN, M.D.; WILLIAM J. REDDY, A.B.
Synthetic adrenal steroids possessing biologic activity greater than that of the naturally occurring secretory products of the adrenal cortex are of considerable theoretic importance and, in certain instances, may offer unusual opportunities for hormone therapy. Furthermore, it is of particular interest that the isolation and identification of a very active, naturally occurring sodium-retaining adrenal steroid (aldosterone) should have coincided with the synthesis of derivatives of hydrocortisone possessing physiologic activities manyfold greater than those of any previously known naturally occurring steroid. In 1954 Reichstein announced the identification and crystallization of "aldosterone," a naturally occurring adrenal steroid first described by Simpson and
THORN GW, RENOLD AE, MORSE WI, GOLDFIEN A, REDDY WJ. HIGHLY POTENT ADRENAL CORTICAL STEROIDS: STRUCTURE AND BIOLOGIC ACTIVITY(HIGHLY POTENT ADRENAL CORTICAL STEROIDS: STRUCTURE AND BIOLOGIC ACTIVITY*). Ann Intern Med. 1955;43:979–1000. doi: 10.7326/0003-4819-43-5-979
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Published: Ann Intern Med. 1955;43(5):979-1000.
Adrenal Disorders, Endocrine and Metabolism.
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