HENRY L. WILDBERGER, M.D.; WILLIAM R. BARCLAY, M.D.
In 1944 Hamman and Rich1, 2 described three cases of diffuse interstitial fibrosis of the lungs observed by them between 1931 and 1933, and an additional case seen in 1943. These cases were characterized by dyspnea, cyanosis and cor pulmonale attributable to a widespread connective tissue hyperplasia throughout the interstitial structures of the lungs. Several etiologies were considered and discarded as incompatible with the pathologic findings, and the syndrome was believed to represent an acute idiopathic entity.
In the subsequent decade it has become increasingly clear that the syndrome represents a general tissue response of the lungs. This reaction in
WILDBERGER HL, BARCLAY WR. DIFFUSE INTERSTITIAL PULMONARY FIBROSIS1. Ann Intern Med. 1955;43:1127–1138. doi: 10.7326/0003-4819-43-5-1127
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Published: Ann Intern Med. 1955;43(5):1127-1138.
Interstitial Lung Disease, Pulmonary/Critical Care.
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