MILTON S. SACKS, M.D.
Recent studies demonstrating fibrinogenopenia as the basic defect in a widely disparate group of hemorrhagic disorders have aroused renewed interest in this component of the coagulation mechanism. Included among these hemorrhagic disorders are the abnormal bleeding associated with some cases of abruptio placentae, amniotic fluid embolism, retention of a dead fetus in utero, carcinoma of the prostate with metastases, and pulmonary surgery. Interest has also been focused on the implications and applications of the fibrinolytic system which exists normally in the blood. A knowledge of some aspects of fibrinogen metabolism is fundamental to the understanding of these entities.
SACKS MS. FIBRINOGEN DEFICIENCY. Ann Intern Med. ;43:1139–1146. doi: 10.7326/0003-4819-43-5-1139
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Published: Ann Intern Med. 1955;43(5):1139-1146.
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