JEROME W. CONN, M.D., F.A.C.P.; LAWRENCE H. LOUIS, SCD.
Aldosterone, the newly discovered normal adrenal secretory product,1-6 has attracted the attention of a great many clinical investigators because of its apparent rôle in the pathogenesis of a number of clinical disorders. This extremely potent sodium-retaining corticoid has been found to be present in excessive amounts in the urine of edematous nephrotics,7, 8 cardiacs with congestive failure,9, 10 patients with decompensated hepatic cirrhosis11-13 and women with eclampsia.14-16 All of these conditions manifest marked edema, but it is obvious that the primary difficulty in each condition is not due to increased activity of a sodium-retaining steroid. It seems reasonable to assume
CONN JW, LOUIS LH. PRIMARY ALDOSTERONISM, A NEW CLINICAL ENTITY12. Ann Intern Med. ;44:1–15. doi: 10.7326/0003-4819-44-1-1
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Published: Ann Intern Med. 1956;44(1):1-15.
Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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