JERRY K. AIKAWA, M.D.
Since Ord in 18781 applied the name "myxedema" to the peculiar subcutaneous swelling characteristic of adult hypothyroidism, numerous studies have been directed toward the identification of the slimy colloid possessing the chemical characteristics of a mucoprotein which is responsible for this type of swelling. Byrom2 has previously used the external metabolic balance method to study the nature of the disturbance in fluid distribution which may be associated with this abnormal deposition of colloid.
Recent improvements in flame photometry and the current availability of radioactive isotopes of sodium and potassium have made possible a more direct investigation of the disturbances in
AIKAWA JK. THE NATURE OF MYXEDEMA: ALTERATIONS IN THE SERUM ELECTROLYTE CONCENTRATIONS AND RADIOSODIUM SPACE AND IN THE EXCHANGEABLE SODIUM AND POTASSIUM CONTENTS12. Ann Intern Med. ;44:30–39. doi: 10.7326/0003-4819-44-1-30
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Published: Ann Intern Med. 1956;44(1):30-39.
Endocrine and Metabolism, Thyroid Disorders.
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