HERBERT W. COONE, M.D., F.A.C.P.; JAMES W. HUMPHREYS JR., M.D., M.S. (Surgery), F.A.C.S.
The most effective treatment to date for Cushing's syndrome is not pituitary irradiation but subtotal adrenalectomy. This procedure has been reported in the medical literature in approximately 100 cases. There have been relatively few reports on patients with long follow-up in whom adrenocorticotropic hormones (ACTH) and cortisone have been used as supportive measures. A well documented case of this type is reported in this paper. The remarkable reversal of such findings as obesity, hypertension, osteoporosis, 17-ketosteroid production and other stigmata of the syndrome is again noted. As in other cases reported, ACTH and cortisone were found to minimize or eliminate
COONE HW, HUMPHREYS JW. SUBTOTAL ADRENALECTOMY IN CUSHING'S SYNDROME1. Ann Intern Med. ;44:188–198. doi: 10.7326/0003-4819-44-1-188
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Published: Ann Intern Med. 1956;44(1):188-198.
Adrenal Disorders, Endocrine and Metabolism.
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