S. FRED RABINER, M.D.; HERBERT C. LICHTMAN, M.D.; JACQUELINE MESSITE, M.D.; R. JANET WATSON, M.D., F.A.C.P.; VICTOR GINSBERG, M.D., F.A.C.P.; LEON ELLENBOGEN, Ph.D.; WILLIAM L. WILLIAMS, Ph.D.
Addisonian pernicious anemia is a deficiency disease resulting from the lack of a specific gastric secretion which is essential for the optimal absorption in the intestine of orally ingested vitamin B12. Probably a mucoprotein,1, 2 this gastric enzyme, commonly referred to as intrinsic factor,3, 4 is produced by the mucosal cells of the stomach of man and other animals. It has not yet been fully characterized chemically, nor is there available a direct method for detecting its presence in the stomach secretions.
In hematologic relapse the diagnosis of pernicious anemia is readily established by the findings of megaloblastic erythropoiesis, macrocytic
RABINER SF, LICHTMAN HC, MESSITE J, WATSON RJ, GINSBERG V, ELLENBOGEN L, et al. THE URINARY EXCRETION TEST IN THE DIAGNOSIS OF ADDISONIAN PERNICIOUS ANEMIA1. Ann Intern Med. ;44:437–445. doi: 10.7326/0003-4819-44-3-437
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Published: Ann Intern Med. 1956;44(3):437-445.
Hematology/Oncology, Red Cell Disorders.
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