JOHN R. HASERICK, M.D., F.A.C.P.
Demonstration of the cellular aggregation which constitutes the lupus erythematosus (LE) phenomenon in heparinized bone marrow1 was the basis of the first in a series of specific diagnostic procedures in systemic lupus erythematosus (SLE).2 When this phenomenon was also demonstrated in heparinized3 and in clotted4 peripheral blood of patients suffering from this disease, such preparations were also used in laboratory diagnosis. Finally, the reproduction in vitro of the LE phenomenon by adding LE plasma or serum to cells of normal bone marrow5, 6 added another in this series of tests.
Thus, the three types of diagnostic procedures used have in
HASERICK JR. EVALUATION OF THREE DIAGNOSTIC PROCEDURES FOR SYSTEMIC LUPUS ERYTHEMATOSUS1. Ann Intern Med. ;44:497–504. doi: 10.7326/0003-4819-44-3-497
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Published: Ann Intern Med. 1956;44(3):497-504.
Lupus Erythematosus, Rheumatology.
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