SOL KATZ, M.D., F.A.C.P.; ABE GIMBLE, M.D.; GEORGES MCCORMICK, M.D.; BENJAMIN PRESCOTT, Ph.D.
Isoniazid and Salizid (Compound 1595,2 also a hydrazide derivative of isonicotinic acid) are two of the most effective and least toxic antituberculous drugs presently available. Although significant side effects are infrequent from the use of these drugs, peripheral neuritis and convulsions constitute toxic reactions sufficiently severe to require that therapy be discontinued or dosage reduced.
Isoniazid, in therapeutic doses, may produce convulsions which resemble grand mal epilepsy.1 This problem may occur in patients without a previous history of epilepsy. The hazards of isoniazid therapy in epileptics have been reported by Fetterhoff,2 who cited a case of status epilepticus precipitated by
KATZ S, GIMBLE A, MCCORMICK G, PRESCOTT B. GLYCINE AND SODIUM GLUCURONATE IN THE MANAGEMENT OF CONVULSIONS DUE TO HYDRAZIDES1. Ann Intern Med. ;44:576–578. doi: 10.7326/0003-4819-44-3-576
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Published: Ann Intern Med. 1956;44(3):576-578.
Neurology, Seizure Disorders.
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