JOHN M. DENNIS, M.D.
Since Friedlander1 irradiated the enlarged thymus gland of an infant with status lymphaticus in 1907 with excellent symptomatic improvement, irradiation of enlarged thymus glands has been a common practice in this country, particularly between 1930 and 1950. Recently, reports have begun to stress the occurrence of malignancy in those children and adolescents who have had radiation for thymic enlargement and other benign conditions during infancy and early childhood.2, 3, 4, 5
Radiation as a possible etiologic factor in carcinoma of the thyroid gland in children and adolescents was first suggested by Duffy and Fitzgerald2 in 1950. In a series of
DENNIS JM. ASSOCIATION OF IRRADIATION WITH NEOPLASIA IN CHILDREN AND ADOLESCENTS. Ann Intern Med. ;44:579–583. doi: 10.7326/0003-4819-44-3-579
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Published: Ann Intern Med. 1956;44(3):579-583.
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