SIDNEY LEIBOWITZ, M.D., F.A.C.P.
It has been the writer's opinion heretofore that all cases of infectious mononucleosis, if properly studied, would reveal positive heterophil agglutination tests. This statement requires some clarification: from the serologic viewpoint a proper study would mean testing for heterophil antibodies at frequent intervals (preferably weekly) for at least three months before the failure to observe a positive test was acceptable. Furthermore, the heterophil agglutination tests should include absorption with guinea pig kidney and beef cell antigens particularly for titers that are, unabsorbed, within the normal range of 1:56 or lower, or within slightly elevated ranges such as 1:112 or 1:224.
LEIBOWITZ S. PROBABLE INFECTIOUS MONONUCLEOSIS WITHOUT POSITIVE HETEROPHIL AGGLUTINATION TESTS1. Ann Intern Med. ;44:717–737. doi: 10.7326/0003-4819-44-4-717
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Published: Ann Intern Med. 1956;44(4):717-737.
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