WILLIAM E. BELLAMY JR., M.D.; H. PAGE MAUCK JR., M.D.; GORDON R. HENNIGAR, M.D.; MILTON WIGOD
To date there have been 27 reported cases of jaundice attributed to the oral administration of para-aminosalicylic acid (PAS or sodium p-aminosalicylic acid) used in the treatment of tuberculosis.1-13 Of these cases, only four have been reported in the American literature.9, 12, 14 In this entire group of cases only one has come to autopsy, with the pathologic changes in the liver described.12
In view of the wide use of this drug at the present time, we feel it worth while to report a case of jaundice developing in a patient with miliary tuberculosis while on PAS therapy. We believe
BELLAMY WE, MAUCK HP, HENNIGAR GR, WIGOD M. JAUNDICE ASSOCIATED WITH THE ADMINISTRATION OF SODIUM P-AMINOSALICYLIC ACID: REVIEW OF THE LITERATURE AND REPORT OF A CASE1. Ann Intern Med. ;44:764–772. doi: 10.7326/0003-4819-44-4-764
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Published: Ann Intern Med. 1956;44(4):764-772.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Mycobacterial Infections.
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