PAUL W. CLOUGH
Phenylpyruvic oligophrenia (phenylketonuria) is a rare malady which has aroused much interest because it offers the most clear cut example of a serious mental illness which is directly dependent upon a disturbance of metabolism. The disease was first identified by Foelling1 in Norway in 1934, who observed that the urine of certain idiotic children gave an intense green color when tested with ferric chloride solution, the routine test (Gerhardt) for diacetic acid. A systematic search among hundreds of inmates of institutions for the feeble minded brought to light, in all, 10 such cases. He was able to isolate and identify
CLOUGH PW. PHENYLPYRUVIC OLIGOPHRENIA. Ann Intern Med. ;44:819–823. doi: 10.7326/0003-4819-44-4-819
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Published: Ann Intern Med. 1956;44(4):819-823.
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