J. GRAHAM SMITH JR., M.D.
A case of clinically recognizable progressive bacterial synergistic gangrene was reported as early as 1909.1 Two other cases were reported in 1924,2, 3 but it was not until 1926 that Meleney clearly demonstrated the etiology of the infection.
Bacteriologic studies4 were made by Meleney on the lesion of a patient who had developed a progressive gangrene of the abdominal wall following the surgical drainage of an appendiceal abscess. A micro-aerophilic nonhemolytic streptococcus was cultured from far out in the spreading periphery of the lesion. Micrococcus pyogenes var. aureus (hemolytic Staphylococcus aureus) and diphtheroid bacilli were cultured from the
SMITH JG. PROGRESSIVE BACTERIAL SYNERGISTIC GANGRENE: REPORT OF A CASE TREATED WITH CHLORAMPHENICOL1. Ann Intern Med. ;44:1007–1015. doi: 10.7326/0003-4819-44-5-1007
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Published: Ann Intern Med. 1956;44(5):1007-1015.
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